Research Focus

Validation of natural products, nutraceuticals and drug molecules for their therapeutic potential in liver and kidney disease models.

Preclinical safety/toxicity studies

Achievements / Awards

IAVP-Prof. S. Ramachandran Memorial Award 2022

Best Poster Awards (02), SFEC-2022, International Congress of Society of Ethnopharmacology

Best Poster Award, Indian Academy of Biomedical Sciences (2019)

Certificate of Appreciation for a research paper in Dr P.D. Sethi Memorial Annual National Awards -2017

ASRB-NET qualified  (Veterinary Pathology)

Awarded certificate of honour for BVSc & AH 

Awarded merit scholarship in BVSc & AH and MVSc

Awarded Certificate of Merit  under National Scholarships Scheme in Matriculation 

Major Publications

Vikram Patial*, Swati Katoch Jyoti Chhimwal, Garima Dadhich, Vinesh Sharma, Ajay Rana, Robin Joshi, Yogendra Padwad* (2023). Catechins prevent obesity-induced kidney damage by modulating PPARγ/CD36 pathway and gut-kidney axis in rats. Life Sciences. 121437. https://doi.org/10.1016/j.lfs.2023.121437.

Raman Kumar, Vinesh Kumar, Sampa Das, Vikram Patial*, Vidyashankar Srivatsan* (2023). Arthrospira platensis (Spirulina) fortified functional foods ameliorates iron and protein malnutrition by improving growth, modulating oxidative stress and gut microbiota in rats. Food & Function (RSC). https://doi.org/10.1039/D2FO02226E.

Vinesh Sharma, Vikram Patial* (2022). Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases. Frontiers in Pharmacology.13:991059. doi: 10.3389/fphar.2022.991059.

Swati Katoch, Vinesh Sharma, Vikram Patial* (2022). Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma: Experimental and clinical scenarios. World Journal of Gastroenterology, 28(28): 3535-3554. DOI: 10.3748/wjg.v28.i28.3535

Jyoti Chhimwal, Abhishek Goel, Mahesh Sukapaka, Vikram Patial*, Yogendra Padwad* (2022). Phloretin mitigates oxidative injury, inflammation and fibrogenic responses via restoration of autophagic flux in in-vitro and pre-clinical models of NAFLD. Journal of Nutritional Biochemistry, 109062.https://doi.org/10.1016/j.jnutbio.2022.109062.

Desh Raj, Vinesh Sharma, Ashwani Upadhyaya, Neeraj Kumar, Robin Joshi, Vishal Acharya, Dinesh Kumar, Vikram Patial* (2021). Swertia purpurascens Wall ethanolic extract mitigates hepatic fibrosis and restores hepatic hepcidin levels via inhibition of TGFβ/SMAD/NFκB signaling in rats. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2021.114741.

Vikram Patial*, Swati Katoch, Jyoti Chhimwal, Prithvi Pal Singh, Patil Shivprasad Suresh, Yogendra Padwad* (2021). Tinospora cordifolia activates PPARγ pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine, https://doi.org/10.1016/j.phymed.2021.153663.

Jyoti Chhimwal, Vikram Patial, Yogendra Padwad (2021). Beverages and Non-alcoholic fatty liver disease (NAFLD): Think before you drink. Clinical Nutrition. 40 (5): 2508-2519. doi:https://doi.org/10.1016/j.clnu.2021.04.011.

Swati Katoch, Vikram Patial* (2020). Zebrafish: An emerging model system to study liver diseases and related drug discovery. Journal of Applied Toxicology, 1-19 doi:10.1002/jat.4031

Jyoti Chhimwal, Supriya Sharma, Pankaj Kulurkar, Vikram Patial* (2020). Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats: Effect of crocin on liver fibrosis. Human and Experimental Toxicology. 39(12), 1639-49.

Amitabha Acharya, Vikram Patial* (2020). Nanotechnological interventions for the treatment of renal diseases: Current scenario and future prospects. Journal of Drug Delivery Science and Technology. 59:101917.

Supriya Sharma, Mehak, Jyoti Chhimwal, Vikram Patial*, Ugir Hossain Sk (2019). Dendrimer-conjugated podophyllotoxin suppresses DENA-induced HCC progression by modulation of inflammatory and fibrogenic factors. Toxicology Research. 8, 560–567.

Supriya Sharma⁠, ⁠Pallavi Sharma⁠, Pankaj Kulurkar⁠, Damanpreet Singh⁠⁠, Dinesh Kumar*⁠, Vikram Patial* (2017). Iridoid glycosides fraction from Picrorhiza kurroa attenuates cyclophosphamide-induced renal toxicity and peripheral neuropathy via PPAR-γ mediated inhibition of inflammation and apoptosis. Phytomedicine, 36: 108-117.

Supriya Sharma, Shalika Rana, Vikram Patial*, Mahesh Gupta, Shashi Bhushan Yogendra S Padwad (2016). Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice. Human and Experimental Toxicology, 35(12): 1264-75.

Shanka Walia, Supriya Sharma, Pankaj Markand Kulurkar, Vikram Patial*, Amitabha Acharya* (2016). A bimodal molecular imaging probe based on chitosan encapsulated magneto-fluorescent nanocomposite offers biocompatibility, visualization of specific cancer cells in vitro and lung tissues in vivo. International Journal of Pharmaceutics, 498:110-118.

Vikram Patial*, Mahesh S, Supriya Sharma, Kunal Pratap, Damanpreet Singh, Yogendra S. Padwad (2015). Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. Environmental Toxicology and Pharmacology. 40: 445-452.

Research Group

PhD Scholars:

Vinesh Sharma- ICMR SRF

Swati Katoch- PA

Prakriti Sharma- CSIR JRF

Vivek Kumar- CSIR GPAT

Shagun Dogra- ICMR SRF

Sahiba Chahal- CSIR JRF